Endocrine Abstracts

Introduction: Liraglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist, approved for the treatment of adult patients with type 2 diabetes mellitus of a particular interest in the significant improvement of glycaemic, systolic blood pressure and lipid control with their impact on weight, making it possible to avoid this infernal spiral of weight gain-increased insulin resistance.Observation: 55-year-old female patient, known diabetic for 10 years...

Background: Pheochromocytoma is a rare tumour that arise from chromaffin cells in the adrenal medulla and produces signs and symptoms due to excessive catecholamine secretion from tumour. Presenting symptoms can vary but often they classically present with headaches, sweating and palpitations in the setting of paroxysmal hypertension. Pheochromocytoma crisis results from the sudden release of large quantities of catecholamines and leads to progressive multiple organ dysfunctio...

Over a third of women with polycystic ovarian syndrome (PCOS) display glucose intolerance and multiple risk factors for cardiovascular disease, including central obesity. Interleukin-6, a cytokine that is mainly derived from adipose tissue, has recently been implicated as an important link in the development of cardiovascular disease in obesity. We determined the relations between circulating Interleukin-6 levels and anthropometric, metabolic and hormonal parameters in 38 wome...

Introduction: LADA (Latent Autoimmune Diabetes in Adults), is defined by the association of diabetes after 30 years, the presence of antibodies against pancreatic beta cells and the non-use of insulin therapy within 6 months of diagnosis. Graves’ disease is the first cause of hyperthyroidism associating thyrotoxicosis, goiterand exophthalmos with a prevalence 5 times higher in women.Case report: 37-year-old female patient with no notable history, la...

Sarcoidosis is a multiorgan disease often affecting the lungs and lymphatic system. Neurological involvement occurs in sarcoidosis as granulomas infiltrate the nervous system. Here, we present a case of neurosarcoidosis diagnosed following non-specific neurological symptoms and delayed hypercalcaemia. A 32-year-old female presents with headaches, vomiting and acute confusion. During admission she developed unresponsive episodes. She has a background of type 1 diabetes and hypo...

Background: Several cytokines and chemokines are released by adipose tissue and associated with insulin resistance. We investigated the systemic and in vitro release of RANTES(Regulated upon Activation Normal T-cell Expressed and Secreted), MCP-1(Monocyte Chemo-attractant Protein-1), adiponectin, leptin and IL-6 from three human adipose tissue depots and their relationship to insulin sensitivity.Methods: Fasting blood samples were taken from obese...

IntroductionWomen with Turner Syndrome (TS) have an increased risk of diabetes mellitus (DM), both types 1 and 2, and obesity is a common problem. This study aimed to characterise the relationship between markers of obesity and metabolic factors which might predispose to DM.MethodAnthropometric and fasting metabolic assessments were performed in 56 non-diabetic women with TS and 24 control women (mean±...

Introduction and objectives: The most important risk factors of chronic kidney disease (CKD) are diabetes and hypertension. In addition, obesity and metabolic syndrome (MetS) are independent predictive factors of CKD. The objective of our study was to investigate if MetS affects renal function of patients who underwent partial nephrectomy for localized renal cell carcinoma (RCC).Patients and methods: 50 cases of T1N0M0 RCC patients who underwent partial ...

Covid-19 infection severity has been associated with pre-existing conditions including obesity. Individuals with Down Syndrome (DS) are potentially at high risk. Reports on the outcomes of Covid-19 infection in individuals with DS are scant. Here we present such a case. MA is a 27-year old Emirati male with DS, obesity and hypothyroidism. He was brought to the ER with a history of hemoptysis (2 days), fever and cough (1 week). He tested positive for Covid-19. Initial investiga...

Introduction: Most pituitary adenomas are benign. However, there are invasive forms with rapid growth rate and particular histological signs (atypical adenomas), making them considered pituitary carcinomas without metastases.Observation: A 63-year-old patient was followed for 10 years for Cushing’s disease in the pituitary macrodenoma. Clinical evaluation found Cushing syndrome, pituitary tumor syndrome associated with diplopia, and trigeminal neura...